An experimental study on the bone regeneration of mandibular bone defects: The effect on periosteum.

DOI 7 Citations
  • ORIYA Shigeru
    The Second Department of Oro-Maxillo-Facial Surgery, School of Dentistry Aichi-Gakuin University

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  • 下がく骨骨欠損部の骨再生に関する実験的研究　　特に骨膜の影響について
  • The effect on Periosteum
  • 特に骨膜の影響について

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Abstract

We often encounter the cases in which periosteum with bone defects cannot be preserved because of surgical resection of tumors or injuries. Bone and periosteum transplantation are generally accepted for repair in these cases. However, there are a few reports that experimental healing process of bone defects without periosteum in the mandibular bone has been observed. This investigation was undertaken to study healing process of the amputation stump in the mandibular jaw defects of the adult dogs in such experimental situations as lack of the ability of bone formation by periosteum and bone transplantation. Thirty-nine adult dogs were used in this study. Experimenal bone defects with spacing of 10 × 15 mm were made in the mandibular bone.<BR>They were divided into two groups for comparison:<BR>A) The defect was covered with silicon sheet after preserving the inferior alveolar artery and vein.<BR>B) The defect was left uncovered after preserving the inferior alveolar artery and vein. Process of bone healing was observed for 7 months. Four different fluorochromes were administered in order to estimate activity and the source of bone formation for the period. Biopsy specimens for light microscopy and fluorescence microscopy were obtained, and radiographic examination was also performed.<BR>The results obtained were as follows:<BR>1) The bone repair in one of A group began in 5 months. However, bone formation was found in one-half of the number of cases in A group and the outline of the mandibular bone was repaired to almost normal size in 7 months.<BR>2) The bone formation in B group terminated in 3-5 months, but a small concavity in the normal outline of the mandibular bone could be seen after 7 months.<BR>When the inferior alveolar artery and vein are preserved, the inserted silicon sheet prevents formation of the fibrous scar tissue and pressures from the surrounding tissue. Therefore, bone formation fills up bone defects without the bone graft and/or preservation of periosteum.

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