Epidemiologic studies on cleft lip and/or palate: Part 2. A case-control study (I): Epidemiologic backgrounds of subjects and maternal episodes during early pregnancy.

DOI 2 Citations
  • TOHNAI Iwai
    Department of Oral Surgery, Nagoya University School of Medicine
  • OKA Tohru
    Department of Oral Surgery, Nagoya University School of Medicine
  • OHNO Yoshiyuki
    Department of Public Health, Nagoya City University Medical School

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Other Title
  • しん・がく・口がい裂の疫学的研究　ＩＩ　　症例‐対照研究　１　　症例・対照の疫学特性および妊娠初期における母親の疫学特性
  • A case-control study (I): Epidemiologic backgrounds of subjects and maternal episodes during early pregnancy
  • 症例-対照研究 (I): 症例・対照の疫学特性および妊娠初期における母親の疫学特性

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Abstract

To explore the factors related to the development of cleft lip and/or palate, a case-control study was attempted, based on 194 cases and 194 controls.<BR>Cases were incident cases born alive in five areas from April, 1978 to September, 1981. Controls were selected from normal infants in five major hospitals; matched for residence, sex, birth order and maternal age at birth. Epidemiologic information was collected by direct interview of mothers, using a questionnaire designed particulaly for this study.<BR>Major findings of interest are as follows:<BR>(1) Seasonal frequency of birth, birth place, gestational period, and presentation were not significantly different between cases and controls.<BR>(2) Mean birth weight and mean head circumference at birth were also not significantly different between cases and controls.<BR>(3) On an average, cases were significantly shorter at birth than controls in both sexes. Mean chest circumferences at birth in males were also much smaller in cases than in controls.<BR>(4) Among maternal episodes during early pregnancy, X-ray irradiation history and drinking habits of alcoholic beverages were similar between cases and controls.<BR>(5) Mothers had suffered from diseases and ingested drugs more often in cases than in controls, with statistical significance. Smoking mothers were also significantly more prevalent in cases.

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