Antioxidative Mechanism and Apoptosis Induction by 3-Hydroxyanthranilic Acid, an Antioxidant in Indonesian Food Tempeh, in the Human Hepatoma-Derived Cell Line, HuH-7.
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- MATSUO Masako
- General Education, Gifu Women's University
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- NAKAMURA Noriaki
- First Department of Internal Medicine, Gifu University School of Medicine
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- SHIDOJI Yoshihiro
- First Department of Internal Medicine, Gifu University School of Medicine
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- MUTO Yasutoshi
- First Department of Internal Medicine, Gifu University School of Medicine
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- ESAKI Hideo
- Department of Food and Nutrition, Sugiyama Jyogakuen University
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- OSAWA Toshihiko
- Department of Applied Biological Sciences, Nagoya University
書誌事項
- タイトル別名
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- Antioxidative Mechanism and Apoptosis I
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抄録
Recently, a new potent antioxidant was isolated from Tempeh (a traditional fermented soybean food in Indonesia) and was identified as 3-hydroxyanthranilic acid (HAA). This study deals with the antioxidant mechanism of HAA under biological systems and the cytokill-ing function of HAA to human malignant cells. HAA eliminated free radicals and inhibited the formation of fatty acid hydroperoxide in vitro, suggesting that HAA would serve as an antioxidant in the initial reaction in lipid oxidation systems. Actually, HAA inhibited the formation of the dominant product of membrane lipids, 12-hydroxyeicosatetraenoic acid (12-HETE) at a high concentration, while HAA accelerated 12-HETE formation at a low concentration in mammalian tissue. HAA oxidized glutathione and inhibited superoxide dismutase in vitro. Furthermore, HAA inhibited cell growth and induced apoptosis to HuH-7, a human hepatoma-derived cell line. As long as HAA is taken as a component of Tempeh, and not in large doses as a chemical, it may possibly act as a prooxidant rather than an antioxidant in vivo.
収録刊行物
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- Journal of Nutritional Science and Vitaminology
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Journal of Nutritional Science and Vitaminology 43 (2), 249-259, 1997
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詳細情報 詳細情報について
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- CRID
- 1390282681299566080
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- NII論文ID
- 130001370277
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- NII書誌ID
- AA00703822
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- COI
- 1:CAS:528:DyaK2sXjslemu78%3D
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- ISSN
- 18817742
- 03014800
- http://id.crossref.org/issn/03014800
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- NDL書誌ID
- 4231099
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- PubMed
- 9219098
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可