Vitamin E Reduces Glucocorticoid-Induced Oxidative Stress in Rat Skeletal Muscle.
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- OHTSUKA Akira
- Department of Biochemical Science and Technology, Faculty of Agriculture, Kagoshima University
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- KOJIMA Hiroshi
- Department of Biochemical Science and Technology, Faculty of Agriculture, Kagoshima University
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- OHTANI Takayuki
- Department of Biochemical Science and Technology, Faculty of Agriculture, Kagoshima University
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- HAYASHI Kunioki
- Department of Biochemical Science and Technology, Faculty of Agriculture, Kagoshima University
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The purpose of this study was to investigate the effect of vitamin E on oxidative stress in the skeletal muscle of glucocorticoid-treated rats. Male Sprague-Dawley rats (5 weeks of age) were fed a basal diet or a diet supplemented with vitamin E (5, 000 mg DL-α-tocopheryl acetate/kg diet) for 10 d. The rats of both diet groups received subcutaneous injections of corticosterone (CTC) (0, 25, and 100mg/kg body weight/d) during the final 4d. Weights of the extensor digitorum longus and gastrocnemius (CAST) muscles were dose-dependently reduced by CTC. However, the muscle weight losses in rats fed the vitamin E diet were smaller than those in rats fed the basal diet. Protein carbonyl content in the GAST muscle, which was determined as an index of oxidatively modified protein, was increased by 100mg of CTC, and the increment was significantly (p<0.01) reduced by vitamin E supplement. Hypergly-cemia was induced by 100mg of CTC, but it was not affected by vitamin E. Lipid peroxide (TBARS) in plasma and in GAST muscle was elevated by 100mg of CTC, and vitamin E significantly (p<0.001) suppressed the formation of TBARS in the muscle. The change in TBARS paralleled that in protein carbonyl. These results show that CTC leads to oxidative stress in rat skeletal muscles and that vitamin E has roles in reducing the oxidative stress which causes muscle atrophy.
収録刊行物
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- Journal of Nutritional Science and Vitaminology
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Journal of Nutritional Science and Vitaminology 44 (6), 779-786, 1998
一般財団法人 学会誌刊行センター
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詳細情報
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- CRID
- 1390282681299160960
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- NII論文ID
- 130001370531
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- NII書誌ID
- AA00703822
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- ISSN
- 18817742
- 03014800
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- NDL書誌ID
- 4649708
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- PubMed
- 10197309
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可