Effects of Long-Term Administration of Hesperidin and Glucosyl Hesperidin to Spontaneously Hypertensive Rats.
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- OHTSUKI Kazumasa
- Department of Animal Science, Faculty of Agriculture, Okayama University
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- ABE Asaki
- Department of Animal Science, Faculty of Agriculture, Okayama University
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- MITSUZUMI Hitoshi
- Hayashibara Biochemical Laboratories, Inc.
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- KONDO Masaru
- Department of Animal Science, Faculty of Agriculture, Okayama University
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- UEMURA Kanae
- Department of Animal Science, Faculty of Agriculture, Okayama University
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- IWASAKI Yumiko
- Department of Animal Science, Faculty of Agriculture, Okayama University
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- KONDO Yasuhiro
- Department of Animal Science, Faculty of Agriculture, Okayama University
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抄録
Hesperidin (LIES) is a flavonoid contained in citrus fruit peel. We investigated the effects of long-term administration of HES and its newly developed water soluble analogue, glucosyl hesperidin (GHES), to spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY). Animals were fed with diets containing HES or GHES (30 mg/d/kg body weight) for 25 wk. While the daily food intake and the body weight of administered rats were not different from those of the non-administered control rats in both SHR and WKY through the experimental period, the blood pressure and heart rate of SHR administered HES or GHES for longer than 15 wk decreased as compared to the control group. The blood pressure and heart rate of WKY were not changed by the long-term administration of HES or CHES. These results suggest that HES and GHES have anti-hypertensive effects on hypertensive animals.
収録刊行物
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- Journal of Nutritional Science and Vitaminology
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Journal of Nutritional Science and Vitaminology 48 (5), 420-422, 2002
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詳細情報 詳細情報について
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- CRID
- 1390282681301092736
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- NII論文ID
- 130001377218
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- NII書誌ID
- AA00703822
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- COI
- 1:CAS:528:DC%2BD3sXnvFKgsw%3D%3D
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- ISSN
- 18817742
- 03014800
- http://id.crossref.org/issn/03014800
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- NDL書誌ID
- 6414739
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- PubMed
- 12656219
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可