ＬＰＳ処理単球系細胞株（Ｕ９３７）のｈｏｍｏｔｙｐｉｃ　ｃｅｌｌ　ａｇｇｒｅｇａｔｉｏｎを誘導するモノクローナル抗体

• 池脇 信直

  北里大学看護学部感染学教室

• 笹原 武志

  北里大学医学部微生物学教室

• 玉内 秀一

  北里大学医学部微生物学教室

• 猪子 英俊

  東海大学医学部分子生命学教室

書誌事項

タイトル別名

• Establishment of monoclonal antibody mNI-11 which induces homotypic cell aggregation of LPS-treated U937 cells.
• LPS ショリ タンキュウケイ サイボウカブ U937 ノ homotypic

抄録

A mouse monoclonal antibody (mAb), designated as mNI-11, was produced. The reactivity of mNI-11 was assessed by immunofluorescence assay with various cells. Myelomonocytic cell line, U937, and lipopolysaccharide (LPS)-treated U937 (LPS-U 937 cells) were found to bind strongly to the mAb. EBV-B cell line and peripheral blood mononuclear cells (PBMCs) were found to bind moderately to it. This mAb strongly induced homotypic cell aggregation of LPS-U937 cells. The mAbs to CD 18 and CD 54 completely inhibited the LPS-U 937 cell aggregation induced by mNI-11. The surface antigens of the U 937 and LPS-U 937 cells recognized by mNI-11 had a molecular size of 95-97kDa as determined by immunoblotting analysis.

収録刊行物

• 日本細菌学雑誌

  日本細菌学雑誌 48 (6), 739-743, 1993

  日本細菌学会

キーワード

• General Medicine

詳細情報

• CRID: 1390282681426392704
• NII論文ID: 130001386988
• NII書誌ID: AN00189800
• DOI: 10.3412/jsb.48.739
• ISSN: 18824110
• ISSN: 00214930
• NDL書誌ID: 3856109
• PubMed: 7905939
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I3856109
• Web Site: https://search.jamas.or.jp/link/ui/1995103610
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可