頬の表皮構造による毛穴目立ちと,その改善へのアプローチ  [in Japanese] An Approach to Improvement of Pore Conspicuousness Caused by Epidermal Structure on Cheek  [in Japanese]

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Author(s)

Abstract

毛穴目立ちは多くの女性のもつ悩みの一つであるが,その目立つ原因は明らかになっていない。われわれは生体用レーザー顕微鏡を使用して頬の表皮構造を詳細に観察し,毛孔周囲が凹んでいる毛孔では特徴的な表皮の構造をもつことを明らかにした。この表皮構造は表皮が非常に深くまで落ち込んでおり,非常に長く伸長した真皮乳頭をもつことを特徴としていた。この表皮構造は表面の凹みと面積・形状が同じであることから,頬において毛穴が目立つ一因であると考えられた。そこで,表皮の収縮に着目して表皮構造を改善する剤の探索を行い,表皮細胞の収縮促進と増殖抑制の効果をもつ1-イソステアリルグリセロール-3-リン酸を見出した。ヒトでの使用試験の結果,1-イソステアリルグリセロール-3-リン酸は表皮構造に変化を起こさせ,目立つ毛穴に対する改善効果をもつことを確認した。今回,これら表皮に着目した毛穴目立ち改善へのアプローチについて報告する。

Conspicuous facial pores are one of the more serious aesthetic defects of concern to most women. However, the mechanism that causes the conspicuousness of facial pores remains unclear. We observed the epidermal structure around the conspicuous pores on cheeks <i>in vivo</i> using a confocal microscope in detail, and found that there were peculiar epidermal structures around the conspicuous facial pores. These epidermal structures were characterized by a thick epidermis, which reached the deep dermis, and elongated dermal papillae. As the shape and the size of these epidermal structures at more than one hundred micrometers below the surface were similar to those of the surface hollow area around the conspicuous pores, we thought that this epidermal structure was one cause for facial pore conspicuousness on cheeks. To improve these epidermal structures through contraction of keratinocytes, we developed 1-isostearylglycerol-3-phosphate, which promoted the gel contractile ability of keratinocytes and suppressed the keratinocytes' growth <i>in vitro</i>. The treatment of lotion containing 1-isostearylglycerol-3-phosphate could alter the epidermal structures and decrease the hollow area around the conspicuous facial pores.

Journal

  • Journal of Society of Cosmetic Chemists of Japan

    Journal of Society of Cosmetic Chemists of Japan 43(1), 3-9, 2009

    The Society of Cosmetic Chemists of Japan

Codes

  • NII Article ID (NAID)
    130001473204
  • NII NACSIS-CAT ID (NCID)
    AN00101606
  • Text Lang
    JPN
  • ISSN
    0387-5253
  • NDL Article ID
    10240207
  • NDL Source Classification
    ZP25(科学技術--化学・化学工業--油脂類)
  • NDL Call No.
    Z17-820
  • Data Source
    NDL  J-STAGE 
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