シリコーン中空糸を用いた落差潅流方式外部潅流型膜型人工肺の開発  [in Japanese] Development of outside flow type membrane oxygenator using silicone hollow fiber.  [in Japanese]

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Abstract

シリコーン中空糸を用いた新しい膜型人工肺を開発した。熱交換器の周りに巻かれたシリコーン中空糸の外部を静脈血は落差で灌流し、ガス交換され動脈血が貯血される膜型肺である。実験は緬羊10頭を、高灌流量群(Qb=4.7±0.5L/min、6頭)、低灌流量群(Qb=11/min、4頭)に分け、8時間の常温体外循環を実施し、ガス交換能や血液適合性の検討を行った。全例順調に8時間の体外循環が実施できた。V/Q1の条件下、両群ともにガス交換能は良好であつた。また8時間の体外循環中、ガス交換能は安定しており経時的低下は認められなかつた。溶血、血小板数の変化、血中酵素の上昇は僅かであつた。フイブリノーゲンの消費も認められなかつた。本人工肺はガス交換能や血液適合性に優れ、動脈血貯血方式のため、拍動流や分離体外循環にも対処し得る膜型肺である。

A new develolped membrane oxygenator consists of silicone hollow fiber membrane oxygenator, heat exchanger and arterial blood reservoir. As outside flow type is employed in this oxygenator, gas transfer is realized by gravity venous drainage. Animal experiments using 10 sheep were carried out, in normothermic CPB for 8 hours (high flow group 4.7±0.5L /min, low flow group 1L/min). Performances of this oxygenator were evaluated in gas transfer capability and hematological exatnination. Blood gas was maintained with high PO<sub>2</sub> and acceptable PCO<sub>2</sub> levels throughout CPB. Plasma free hemoglobin was significanty low compared with polypropylene hollow fiber oxygenator. Consumption of platelet and fibrinogen was also maintained within physiological levels. These results suggest that this oxygenator has high performance of gas exchange with least blood cell trauma and also useful for pulsatile and/or separating CPB because of arterial blood reservoir.

Journal

  • Jinko Zoki

    Jinko Zoki 20(2), 381-384, 1991

    JAPANESE SOCIETY FOR ARTIFICIAL ORGANS

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