人工すい臓　　ＴｉＯ２型酸素電極を基礎とした針状グルコースセンサーの改良と動物実験結果

• 木村 正美

  名古屋工業大学応用化学科

• 池田 章一郎

  名古屋工業大学応用化学科

• 伊藤 要

  名古屋工業大学応用化学科

• 大倉 國利

  名古屋大学医学部第二外科

• 中尾 昭公

  名古屋大学医学部第二外科

• 高木 弘

  名古屋大学医学部第二外科

• 近藤 達平

  名古屋大学

書誌事項

タイトル別名

• Artificial pancreas - Improvement of the needle type glucose sensor based on titanium dioxide oxygen electrodes and its experimental use in a dog.
• -IMPROVEMENT OF THE NEEDLE TYPE GLUCOSE SENSOR BASED ON TITANIUM DIOXIDE OXYGEN ELECTRODES AND ITS EXPERIMENTAL USE IN A DOG-
• ―TiO₂型酸素電極を基礎とした針状グルコースセンサーの改良と動物実験結果―

抄録

The needle type glucose sensor has been developed and improved using a new type oxygen electrode composed of a Ti wire of which surface was anodically oxidized, and examined in vivo animal tests. The deviation of the output current with time of the oxygen electrode system as indicated in the previous paper has been decreased by heat sealing of the Ti wire in a glass capillary. Several surface analysis technics have been employed to investigate the surface characteristics of the oxygen electrode system and the glucose sensor. The oxide layer has proved to be TiO₂ by Auger and ESCA analyses. It has been confirmed that -O-Si-(CH₂)₃NH₂ groups were introduced to the TiO₂ surface, which served the firm immobilization of the enzyme, by FTIR analysis. In vivo IVGTT using a normal dog, the sensor immplanted in the subcutaneous tissue has responded the blood glucose levels, although improvements in the response time and stability are still required.

収録刊行物

• 人工臓器

  人工臓器 18 (3), 1316-1319, 1989

  一般社団法人 日本人工臓器学会

キーワード

• Artificial pancreas
• Titanium dioxide
• Glucose sensor
• Immobilized enzyme

詳細情報

• CRID: 1390282679935293440
• NII論文ID: 130001733919
• DOI: 10.11392/jsao1972.18.1316
• ISSN: 18836097
• ISSN: 03000818
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可