急性左心不全時に補助人工心臓が局所心筋血流量及び心筋代謝に与える影響について

• 松本 直晃

  山口大学第一外科

• 森 文樹

  山口大学第一外科

• 西健 太郎

  山口大学第一外科

• 江里 健輔

  山口大学第一外科

• 毛利 平

  東北大学胸部外科

書誌事項

タイトル別名

• The effect of the left ventricular assist device during reperfusion after acute coronary occlusion.

抄録

We evaluated the effects of the left ventricular assist device (LVAD) for regional myocardial blood flow and myocardial lactate metabolism during reperfusion after one hour occlusion of left circumfrex (LCx) artery. Sixteen mongrel dogs were divided into two groups: nine were supported with LVAD during reperfusion (LVADgroup), and seven without LVAD (Control group). There was no significant difference between two groups for heart rate, aortic pressure, and PA pressure throughout study period. Left atrial pressure was significantly low and, cardiac output, LV dp/dt, left ventricular stroke work were significantly high in the LVAD group compared to the control group. Regional myocardial blood flow in LCx area recovered to the baseline level in the LVAD group, while it remained significantly lower in the control group. The LVAD group showed a positive myocardial lactate extraction in early reperfusion period in spite of persistent lactate production in the control group. In conclusion, the unloading effect by applying LVAD during reperfusion after acute coronary artery occlusion provided the improvement in the regional myocardial blood flow and the myocardial lactate metabolism. Consequently, the left ventricular function showed better recovery after weaning from the LVAD support.

収録刊行物

• 人工臓器

  人工臓器 17 (3), 993-996, 1988

  一般社団法人 日本人工臓器学会

キーワード

• left ventricular assist device
• reperfusion injury
• regional myocardial blood flow
• myocardial lactate extraction

詳細情報

• CRID: 1390282679935366528
• NII論文ID: 130001734462
• DOI: 10.11392/jsao1972.17.993
• ISSN: 18836097
• ISSN: 03000818
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可