コラーゲン‐ムコ多糖からなるハイブリッド多相系生医学材料‐血小板粘着阻止活性と生体親和性の評価

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  • Platelet adhesion to collagen/mucopolysaccharide hybrid matrix

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Collagen is a major component of the extracellular matrix in living tissues and can influence the adhesion, morphology and migration of cells and in some cases, differentiation. On the other hand, since mucopolysaccharides (glycosaminoglycans) possess multiple anionic charges and have strong affinity for water, the resulting water layer may inhibit adhesion of platelets to the surfaces. For this reason, a hybrid matrix consisting of collagen and mucopolysaccharide may be a blood- and tissue-compatible material. Our results indicate that collagen/hyaluronic acid matrix markedly inhibits platelet adhesion, furthermore, the proliferation of fibroblasts on collagen/hyaluronic acid matrix as well as on collagen matrix is well.

収録刊行物

  • 人工臓器

    人工臓器 12 (1), 327-330, 1983

    一般社団法人 日本人工臓器学会

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