新しく開発した粉状活性炭シートを用いた人工肝補助装置の研究　　ビリルビン除去を中心に

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  • Developement of new type activated charcoal sheet-Polyporous polyurethane sheet-embedded powdered activated charcoal (UPC) for fulminant hepatic failure
  • ―ビリルビン除去を中心に―

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A hemoperfusion system has been developed in which powdered activated charcoal are embedded in a polyporous polyurethane sheet.<br>In vitro adsorption studies have revealed that tree adsorption of bilirubin and other albumin bound substance by UPC is superior to that by non-coarted charcoal beads with low release of charcoal micro-particles.<br>During batch test removal rate of bilirubin in jaundice dog serum was about 60% by UPC.<br>Dogs with ligated bile duct were subjected to direct hemoperfusion (DHP) through UPC.<br>As a result of these studies, removal rats of bilirubin was about 40%.<br>There was a transient decrease in platelet and WBC during DHP with gradual recovery to the prevalue at the end of therapy.<br>These studies suggest the UPC-DHP is effective in the treatment of FHF.

収録刊行物

  • 人工臓器

    人工臓器 10 (6), 1037-1040, 1981

    一般社団法人 日本人工臓器学会

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