へん平上皮細胞への移行を伴った巨大な歯原性明細胞癌とその病理組織学的研究

• 今村 英夫

  佐賀医科大学歯科口腔外科学教室

• 久保田 英朗

  佐賀医科大学歯科口腔外科学教室

• 范 江霖

  佐賀医科大学病理学教室

• 片野 光男

  佐賀医科大学外科学教室

• 黒河 博之

  佐賀医科大学歯科口腔外科学教室

• 渡辺 照男

  佐賀医科大学歯科口腔外科学教室

• 香月 武

  佐賀医科大学歯科口腔外科学教室

書誌事項

タイトル別名

• The clinicopathological study of a huge clear cell odontogenic carcinoma with partial transformation into a squamous cell.

抄録

Malignant tumor consisting of elk, r. cells is often seen in the kidney and several other organs. This tumor, however, rarely occurs in oral and, maxillofacial regions. We recently experienced a huge clear cell carcinoma in a 79-year-old female, which putatively originated in the mandible, and o expansile into the right maxilla. zygoma, temporal bone, orbital, and partially into the cranium. Lymphnode (LN) metastasis was observed in the right submandibular LN.<BR>Histopathologically, the tumor was primarily composed of large sheets and islands of uniform vacuolated and clear cells separated by a mature fibrous connetive tissue. The tumor contained no glandular epithelial cells or myoepithelial cells. PAS positive and diastase digestable granules were observed in a small number of tumor cells.<BR>Immunohistochemical examination revealed that the tumor cells focally showed positive reaction to keratin (KT) and epithelial membrane antigen (EMA), but completely negative for actin, S-100, vimentin, and myosin.<BR>Ultrastructurally, the tumor cells were characterized by the presence of abundant cytoplasm and lack of intracellular organelles. Tonofilaments and desmosomes were, however, occasionally observed. From all of these findings, it is considered that the tumor cell may be derived from the odontogenic epithelium and mimick to clear cell odontogenic tumor.<BR>More interestingly, it was found that the tumor partially showed squamous cell differentiation after chemotherapy and immunotherapy. It is likely that the clear cell tumor may transform into squamous cell during differentiation process or vice versa, or the tumor may initially consist of two different kinds of tumor cells.<BR>The histogenesis of the tumor and its potential possiblility to differentiate into squamous epithelium are discussed.

収録刊行物

• 日本口腔外科学会雑誌

  日本口腔外科学会雑誌 37 (12), 2026-2034, 1991

  社団法人 日本口腔外科学会

キーワード

• 明細胞腫
• 歯原性上皮
• 分化

詳細情報

• CRID: 1390001206529282048
• NII論文ID: 130001781583
• DOI: 10.5794/jjoms.37.2026
• ISSN: 21861579
• ISSN: 00215163
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可