めまいを早期症状とする多発性硬化症３症例

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  • Neuro-otological findings in three cases of nultiple sclerosis presenting with vertigo or dysequilibrium as an early symptom.

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1. Three patients with multiple sclerosis presented with vertigo or dysequilibrium as an early symptom.<br>2. Neurootological examination showed abnormal findings in all three cases.<br>3. Gaze nystagmus, direction-changing positional nystagmus, rebound positional nystagmus and vertical positioning nystagmus were observed in these patients, indicating a disturbance of the central vestibular system.<br>4. MLF (medial longitudinal fasciculus) syndrome, indicating a brainstem lesion, was present in two patients.<br>5. Caloric testing was performed in two patients. The duration and the slow phase velocity of the caloric-induced nystagmus were within normal limits, while visual suppression of the caloric-induced nystagmus was impaired in both patients.<br>6. The optokinetic nystagmus pattern test was performed in two patients. The optokinetic nystagmus was markedly depressed when the patients first visited the vestibular clinic shortly after the onset of the vertiginous attack. It gradually improved towards normal during the course of the disease in close correlation with recovery from other neurological signs and symptoms.

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