鼻アレルギーに対する Histaglobin の臨床効果:二重盲検試験による検討 Clinical Effect of Histaglobin on Nasal Allergy:Double Blind Study

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1. 臨床的に鼻アレルギーと診断された120症例中脱落26例を除いた94症例について, Gamma globulin を Placebo としてHGの二重盲検法による治験を行い, 著効5症例, 有効18症例, やや有効13症例, 無効11症例の成績を得た. やや有効を有効例に含めた有効率は76.6%, やや有効を無効例に含めた有効率は48.9%で, いずれの場合も Placebo 群の有効率を上回った.<br>2. 鼻症状の改善では, 鼻閉の改善においては有意差が認められなかったが, くしゃみ, 鼻汁の改善および総合鼻症状改善度では有意差が認められた.<br>3. 鼻粘膜所見の改善では, 分泌物の量については有意な改善が認められなかったが, 下甲介腫脹, 色調および総合鼻粘膜所見改善度については有意差が認められた.<br>4. 総合改善度については, 推計学的に明白な有意差が認められた.<br>5. 皮内反応, 誘発反応, 鼻汁中好酸球では両群間の成績に明らかな差はないが, ヒスタミン反応では, H群に有意な改善が認められる.<br>6. 副作用は全例に認められなかった.<br>7. これらの成績からして, 鼻アレルギーに対してHGは十分使用に値する薬剤であると考える.

A double blind study using Histaglobin was carried out on 120 patients with nasal allergy, twenty-six dropped out of the study.<br>The test resulted in 5 “remarkably effective”, 18 “effective”, 13 “rather effective”, and 11 “ineffective” in the Histaglobin group, and 1 “remarkably effective”, 7 “effective”, 13 “rather effective”, and 26 “ineffective” in the placebo group. The “effective” rate including “rather effective” is 76.6% in Histaglobin group and 44.7% in placebo group, and the “effective” rate excluding “rather effective” is 48.9% in Histaglobin group and 17% in the placebo group. In either case, the “effective” rate in the Histaglobin group was superior to rates in the placebo group, and there was a statistically significant difference.<br>A significant difference in the improvement of subjective symptoms was observed with regard to sneezing, nasal discharge, the degree of general subjective symptoms. No significant difference was observed in the degree of improvement of nasal obstruction.<br>For the improvement of the observations of nares, a significant difference was observed in the degree of improvement of the swelling of inferior nasal concha, the color tone, and the general observation of nares, but no significant difference was observed in the improvement of discharge.<br>As to the intracutaneous reaction, challenging reaction, and the changes of the count of eosinocytes in the nasal discharge, no significant difference was observed in the two groups.<br>In Histamine reaction, however, a significant difference was observed in Histaglobin group.<br>Side effects were not observed in any case.

収録刊行物

  • 耳鼻咽喉科臨床

    耳鼻咽喉科臨床 72(11), 1539-1551_2, 1979

    耳鼻咽喉科臨床学会

各種コード

  • NII論文ID(NAID)
    130001815048
  • NII書誌ID(NCID)
    AN00107089
  • 本文言語コード
    UNK
  • ISSN
    0032-6313
  • NDL 記事登録ID
    2203392
  • NDL 刊行物分類
    SC651;SC211;SD0
  • NDL 雑誌分類
    ZS43(科学技術--医学--耳鼻咽喉科学)
  • NDL 請求記号
    Z19-421
  • データ提供元
    NDL  J-STAGE 
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