An Artificial Copper Complex Incorporating a Cell-Penetrating Peptide Inhibits Nuclear Factor-κB (NF-κB) Activation

• Kanemaru Yosuke

  Department of Bioorganic Medicinal Chemistry, Faculty of Life Sciences, Kumamoto University

• Momiki Yumi

  Department of Bioorganic Medicinal Chemistry, Faculty of Life Sciences, Kumamoto University

• Matsuura Saori

  Department of Bioorganic Medicinal Chemistry, Faculty of Life Sciences, Kumamoto University

• Horikawa Tatsufumi

  Department of Bioorganic Medicinal Chemistry, Faculty of Life Sciences, Kumamoto University

• Gohda Jin

  Research Institute for Drug Discovery, School of Pharmacy, Kumamoto University

• Inoue Jun-ichiro

  Research Institute for Drug Discovery, School of Pharmacy, Kumamoto University

• Okamoto Yoshinari

  Department of Bioorganic Medicinal Chemistry, Faculty of Life Sciences, Kumamoto University

• Fujita Mikako

  Division of Cellular and Molecular Biology, Institute of Medical Science, University of Tokyo

• Otsuka Masami

  Department of Bioorganic Medicinal Chemistry, Faculty of Life Sciences, Kumamoto University

書誌事項

タイトル別名

• An Artificial Copper Complex Incorporating a Cell-Penetrating Peptide Inhibits Nuclear Factor-.KAPPA.B (NF-.KAPPA.B) Activation

抄録

Nuclear factor-κB (NF-κB) is an inducible transcription factor activated by a variety of cytokines, and promotes the transcription of genes involved in cancer, inflammation, autoimmune disease, and viral infection, among others. Because of its involvement in numerous disease processes, considerable research has focused on NF-κB as a potential drug target. We previously reported that cupric ion (Cu²⁺) blocks NF-κB activation. However, Cu²⁺ is unsuitable for drug applications. The copper complex of an artificial peptide HPH-Pep (HPH-Pep-Cu²⁺) was a promising alternative, but it did not easily cross the cell membrane. We report the development of a NF-κB inhibiting Cu²⁺ complex with improved cell-penetrating activity arising from the coupling of a Tat peptide to HPH-Pep-Cu²⁺.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 59 (12), 1555-1558, 2011

  公益社団法人 日本薬学会

キーワード

• nuclear factor-κB (NF-κB)
• copper complex
• cell-penetrating peptide
• Tat

詳細情報

• CRID: 1390282679150904064
• NII論文ID: 130001852132
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.59.1555
• ISSN: 13475223
• ISSN: 00092363
• NDL書誌ID: 023321247
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I023321247
• Web Site: http://www.jstage.jst.go.jp/article/cpb/59/12/59_12_1555/_pdf
• 本文言語コード: en
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