9-Azanoradamantane N-Oxyl (Nor-AZADO): A Highly Active Organocatalyst for Alcohol Oxidation

• Hayashi Masaki

  Department of Organic Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University Process Technology Research Laboratories, Daiichi Sankyo Co., Ltd.

• Sasano Yusuke

  Department of Organic Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University

• Nagasawa Shota

  Department of Organic Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University

• Shibuya Masatoshi

  Department of Organic Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University

• Iwabuchi Yoshiharu

  Department of Organic Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University

Abstract

A highly active organocatalyst for alcohol oxidation has been developed. 9-Azanoradamantane N-oxyl (Nor-AZADO 4), constituting an unhindered, stable nitroxyl radical, exhibits superior catalytic activity to 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) and AZADOs in the oxidation of alcohols to their corresponding carbonyl compounds.

Journal

• Chemical and Pharmaceutical Bulletin

  Chemical and Pharmaceutical Bulletin 59 (12), 1570-1573, 2011

  The Pharmaceutical Society of Japan

Keywords

• organocatalyst
• nitroxyl radical
• alcohol oxidation
• aerobic oxidation
• 2-azaadamantane <i>N</i>-oxyl AZADO

Details

• CRID: 1390282679150657664
• NII Article ID: 130001852136
• NII Book ID: AA00602100
• DOI: 10.1248/cpb.59.1570
• COI: 1:STN:280:DC%2BC38%2FjvV2isg%3D%3D
• ISSN: 13475223
• ISSN: 00092363
• NDL BIB ID: 023321287
• PubMed: 22130384
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I023321287
• Web Site: http://www.jstage.jst.go.jp/article/cpb/59/12/59_12_1570/_pdf
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed