A Strontium-90 Sequestrant for First-Aid Treatment of Radiation Emergency
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- Haratake Mamoru
- Graduate School of Biomedical Sciences, Nagasaki University
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- Hatanaka Eisuke
- Graduate School of Biomedical Sciences, Nagasaki University
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- Fuchigami Takeshi
- Graduate School of Biomedical Sciences, Nagasaki University
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- Akashi Makoto
- Research Center for Radiation Emergency Medicine, National Institute of Radiological Sciences
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- Nakayama Morio
- Graduate School of Biomedical Sciences, Nagasaki University
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抄録
In this study, hydrophilic porous polymer beads with phosphonic acid groups (PGMA-EGDMA-TTA-MP) were synthesized, and assessed as a radioactive strontium-90 sequestrant for the treatment of the radiation emergency. Strontium ions were rapidly absorbed into the blood from the gastrointestinal (GI) tract after oral administration to rats, and distributed to the target organ, i.e., bones. Over 40% of the administered strontium was absorbed into the blood, while the remainder was discharged in the feces within 48 h after the administration. When the PGMA-EGDMA-TTA-MP beads were administered to rats subsequent to the strontium solution, the strontium had accumulated less in the femur. Consequently, the oral administration of the PGMA-EGDMA-TTA-MP beads was effective in suppressing the absorption of strontium from the GI tract.
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 60 (10), 1258-1263, 2012
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679155158656
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- NII論文ID
- 130001852358
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- NII書誌ID
- AA00602100
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- COI
- 1:STN:280:DC%2BC3s%2FisFOntA%3D%3D
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- ISSN
- 13475223
- 00092363
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- HANDLE
- 10069/30605
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- NDL書誌ID
- 023971337
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- PubMed
- 23036968
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可