Indomethacin Induction of Metamorphosis from the Asexual Stage to Sexual Stage in the Moon Jellyfish, <i>Aurelia aurita</i>
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We found while screening a chemical library that indomethacin, an inhibitor of prostaglandin biosynthesis, induced strobilation (metamorphosis from the asexual to sexual stage) in the moon jellyfish, <i>Aurelia aurita</i>. Indomethacin initiated strobilation in a dose-dependent manner, but was not involved in the progression of strobilation. Pharmacological experiments suggested that indomethacin could induce strobilation independently of prostaglandin biosynthesis.
- Bioscience, Biotechnology, and Biochemistry
Bioscience, Biotechnology, and Biochemistry 76(7), 1397-1400, 2012
Japan Society for Bioscience, Biotechnology, and Agrochemistry