Free Fatty Acid Receptors and Their Physiological Role in Metabolic Regulation
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- HIRASAWA Akira
- Department of Genomic Drug Discovery Science, Graduate School of Pharmaceutical Sciences, Kyoto University
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- HARA Takafumi
- Department of Genomic Drug Discovery Science, Graduate School of Pharmaceutical Sciences, Kyoto University
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- ICHIMURA Atsuhiko
- Department of Genomic Drug Discovery Science, Graduate School of Pharmaceutical Sciences, Kyoto University
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- TSUJIMOTO Gozoh
- Department of Genomic Drug Discovery Science, Graduate School of Pharmaceutical Sciences, Kyoto University
Bibliographic Information
- Other Title
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- 消化管脂肪酸受容体とその生理作用
- ショウカカン シボウサン ジュヨウタイ ト ソノ セイリ サヨウ
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Abstract
Free fatty acids (FFAs) are not only essential nutrient components, but they also function as signaling molecules in various physiological processes. In the progression of genomic analysis, many orphan G-protein coupled receptors (GPCRs) are found. Recently, GPCRs deorphanizing strategy successfully identified multiple receptors for FFAs. In these FFA receptors (FFARs), GPR40 (FFAR1) and GPR120 are activated by medium- to long- chain FFAs. GPR40 is expressed mainly in pancreatic β-cell and mediates insulin secretion, whereas GPR120 is expressed abundantly in the intestine and regulates the secretion of cholecystokinin (CCK) and glucagons-like peptide-1 (GLP-1), it promotes insulin secretion. Due to these biological activity, GPR40 and GPR120 are potential drug target for type 2 diabetes and selective ligands have been developed. In this review, we provide recent development in the field and discuss their physiological roles and their potential as drug targets.<br>
Journal
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- YAKUGAKU ZASSHI
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YAKUGAKU ZASSHI 131 (12), 1683-1689, 2011-12-01
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390001206127908480
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- NII Article ID
- 130001871764
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- NII Book ID
- AN00284903
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- ISSN
- 13475231
- 00316903
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- NDL BIB ID
- 023352763
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed