Novel Iodocyclization Method Based on the Controlling of Oxidative Aromatization

• OKITSU Takashi

  Kobe Pharmaceutical University

Bibliographic Information

Other Title

• 酸化的芳香化の制御を機軸とするヨード環化反応の開発
• サンカテキ ホウコウカ ノ セイギョ オ キジク ト スル ヨードカンカ ハンノウ ノ カイハツ

Abstract

  We have developed a new method of iodocyclization based on reagent-controlled oxidative aromatization. Our strategy takes advantage of the dual nature of iodine as both an iodinating and an oxidizing agent. This approach enabled “product switch” and enhanced the flexibility of the synthetic pathway toward pyrazoles and isoxazoles. In addition, the iodo moiety of the cyclized product could create further diversity. The utility of our methodology was demonstrated in the synthesis of valdecoxib and its 2,5-dihydro analogs.<br>

Journal

• YAKUGAKU ZASSHI

  YAKUGAKU ZASSHI 131 (9), 1323-1327, 2011-09-01

  The Pharmaceutical Society of Japan

Keywords

• iodocyclization
• oxidation
• pyrazole
• isoxazole
• alkyne

Details

• CRID: 1390001206127883264
• NII Article ID: 130001871938
• NII Book ID: AN00284903
• DOI: 10.1248/yakushi.131.1323
• ISSN: 13475231
• ISSN: 00316903
• NDL BIB ID: 11222503
• PubMed: 21881306
• Web Site: http://id.ndl.go.jp/bib/11222503
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I11222503
• Web Site: https://www.jstage.jst.go.jp/article/yakushi/131/9/131_9_1323/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2012123215
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed