“Activatable” 蛍光プローブの開発に基づく高感度術中がん部位検出の実現

• 浦野 泰照

  東京大学大学院医学系研究科 科学技術振興機構戦略的創造研究推進事業

書誌事項

タイトル別名

• Highly Sensitive and Intraoperative Detection of Tiny Tumors with Novel “Activatable” Fluorescence Probes
• "Activatable"ケイコウ プローブ ノ カイハツ ニ モトズク コウカンド ジュッチュウ ガン ブイ ケンシュツ ノ ジツゲン

抄録

  Several versatile and rational design strategies for novel fluorescence probes including those based on photoinduced electron transfer have been successfully established. Indeed, based on these design strategies, various novel fluorescence probes were successfully developed including those for reactive oxygen species and reporter enzymes. Furthermore, we have succeeded to visualize tiny tumors in living mice by using cancer-specific antibodies tagged with acidic-pH activatable fluorescence probes. Here, I will describe the details of probe design as well as some imaging results with living cells and animals by applying our novel fluorescence probes.<br>

収録刊行物

• 薬学雑誌

  薬学雑誌 132 (4), 397-406, 2012-04-01

  公益社団法人 日本薬学会

キーワード

• fluorescence probe
• photoinduced electron transfer
• reactive oxygen species
• reporter enzyme
• cancer imaging
• pH

詳細情報

• CRID: 1390001206126544128
• NII論文ID: 130001872040
• NII書誌ID: AN00284903
• DOI: 10.1248/yakushi.132.397
• COI: 1:STN:280:DC%2BC38rht12iuw%3D%3D
• ISSN: 13475231
• ISSN: 00316903
• NDL書誌ID: 023639824
• PubMed: 22465914
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I023639824
• Web Site: https://www.jstage.jst.go.jp/article/yakushi/132/4/132_4_397/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2012182474
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可