“Activatable” 蛍光プローブの開発に基づく高感度術中がん部位検出の実現  [in Japanese] Highly Sensitive and Intraoperative Detection of Tiny Tumors with Novel “Activatable” Fluorescence Probes  [in Japanese]

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Author(s)

    • 浦野 泰照 Urano Yasuteru
    • 東京大学大学院医学系研究科|科学技術振興機構戦略的創造研究推進事業 Graduate School of Medicine, The University of Tokyo|Basic Research Program, Japan Science and Technology Agency

Abstract

  Several versatile and rational design strategies for novel fluorescence probes including those based on photoinduced electron transfer have been successfully established. Indeed, based on these design strategies, various novel fluorescence probes were successfully developed including those for reactive oxygen species and reporter enzymes. Furthermore, we have succeeded to visualize tiny tumors in living mice by using cancer-specific antibodies tagged with acidic-pH activatable fluorescence probes. Here, I will describe the details of probe design as well as some imaging results with living cells and animals by applying our novel fluorescence probes.<br>

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 132(4), 397-406, 2012

    The Pharmaceutical Society of Japan

Codes

  • NII Article ID (NAID)
    130001872040
  • NII NACSIS-CAT ID (NCID)
    AN00284903
  • Text Lang
    JPN
  • ISSN
    0031-6903
  • NDL Article ID
    023639824
  • NDL Call No.
    Z19-411
  • Data Source
    NDL  J-STAGE 
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