Impact of Solute Carrier Family 29 Member 1 (SLC29A1) Single Nucleotide Polymorphisms on mRNA Expression in Peripheral Blood Mononuclear Cells

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Author(s)

    • Suzuki Yoshiharu
    • Department of Pharmaceutical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba
    • Homma Masato
    • Department of Pharmaceutical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba
    • Abei Masato
    • Department of Gastroenterology, Graduate School of Comprehensive Human Sciences, University of Tsukuba
    • Hyodo Ichinosuke
    • Department of Gastroenterology, Graduate School of Comprehensive Human Sciences, University of Tsukuba
    • Kohda Yukinao
    • Department of Pharmaceutical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba

Abstract

The effects of solute carrier family 29 member 1 (SLC29A1) single nucleotide polymorphism (SNP), rs6932345 and rs747199, on SLC29A1 mRNA expression were examined. The expression levels of SLC29A1 mRNA in peripheral blood mononuclear cells (PBMCs) isolated from 46 healthy subjects (28 males and 18 females) was compared between wild-type and mutant carriers. The mRNA levels in the rs6932345 wild-type (AA genotype) was 1.71 times that in the mutation carriers (AC/CC genotype) (<i>p</i><0.05). Similar results were observed for rs747199, because rs747199 was linked with rs6932345 at a frequency of 84.8%. It was confirmed that wild-type for rs6932345 and rs747199 showed higher SLC29A1 mRNA expression in PBMCs.

Journal

  • Biological and Pharmaceutical Bulletin

    Biological and Pharmaceutical Bulletin 36(1), 144-146, 2013

    The Pharmaceutical Society of Japan

Codes

  • NII Article ID (NAID)
    130001872060
  • Text Lang
    ENG
  • ISSN
    0918-6158
  • Data Source
    J-STAGE 
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