Diversity and Substrate Specificity in the Structures of Steroidogenic Cytochrome P450 Enzymes
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- Sugimoto Hiroshi
- Biometal Science Laboratory, RIKEN SPring-8 Center
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- Shiro Yoshitsugu
- Biometal Science Laboratory, RIKEN SPring-8 Center
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Abstract
Mammalian cytochrome P450 (CYP) comprise a large group of enzymes that play many important roles in the biosynthesis of steroid hormones and vitamins. In addition, they participate in the metabolism of drugs and xenobiotics. All known mammalian CYP enzymes are membrane-associated proteins, which complicated their X-ray crystallographic analysis. In recent years, however, significant progress has been made in the X-ray crystallographic analysis of mammalian CYP enzymes involved in the steroid hormone and vitamin D3 metabolism. The knowledge from three-dimensional structures of mammalian CYP enzymes will benefit drug discovery and development.
Journal
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- Biological and Pharmaceutical Bulletin
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Biological and Pharmaceutical Bulletin 35 (6), 818-823, 2012
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390282679609589248
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- NII Article ID
- 130001872159
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- NII Book ID
- AA10885497
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- COI
- 1:STN:280:DC%2BC38jgslCisQ%3D%3D
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- ISSN
- 13475215
- 09186158
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- NDL BIB ID
- 023665521
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- PubMed
- 22687469
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed