Anticancer Effects of Residual Powder from Barley-Shochu Distillation Remnants against the Orthotopic Xenograft Mouse Models of Hepatocellular Carcinoma in Vivo

• Ohgidani Masahiro

  Division of Applied Life Science, Graduate School of Engineering, Sojo University

• Ichihara Hideaki

  Division of Applied Life Science, Graduate School of Engineering, Sojo University

• Goto Koichi

  Division of Applied Life Science, Graduate School of Engineering, Sojo University

• Matsumoto Yoko

  Division of Applied Life Science, Graduate School of Engineering, Sojo University

• Ueoka Ryuichi

  Division of Applied Life Science, Graduate School of Engineering, Sojo University

書誌事項

タイトル別名

• Anticancer Effects of Residual Powder from Barley-<i>Shochu</i> Distillation Remnants against the Orthotopic Xenograft Mouse Models of Hepatocellular Carcinoma <i>in Vivo</i>

抄録

Barely-Shochu is a traditional Japanese liquor distilled from fermented barley with Saccharomyces cerevisiae. Barely-Shochu distillation remnants (SDR) are by-products in the manufacturing process of barley-Shochu. We have already reported on valuable powder from Shochu distillation remnants (PSDR) including antioxidative compounds such as polyphenols. In this study, we investigated the therapeutic effects of barely-PSDR against orthotopic xenograft mouse models of hepatocellular carcinoma (HCC) in vivo. We constructed a mouse model of HCC by orthotopical inoculation of HepG2 cells into the liver of SCID mice. Barely-PSDR (2250 mg/kg) was orally treated once each day for 21 d after the inoculation of HepG2 cells. The livers were removed from anaesthetized mice after the treatment with barely-PSDR and fixed in formalin. The liver sections were analyzed by hematoxylin and eosin (HE) staining and terminal deoxynucleotidyl transferase (TdT)-mediated deoxyuridine triphosphate (dUTP) nick-end labeling (TUNEL) methods. Remarkably high reduction of tumorigenesis was obtained in the mouse models of HCC after the oral administration of barely-PSDR in vivo. Induction of apoptosis in the liver section on the mouse models treated with barely-PSDR was observed. Furthermore, prolonged survival was obtained. Thus, therapeutic effects of barely-PSDR without side effects on the orthotopic xenograft mouse models were revealed for the first time.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 35 (6), 984-987, 2012

  公益社団法人 日本薬学会

キーワード

• barely-<i>Shochu</i> distillation remnant
• apoptosis
• human hepatocellular carcinoma
• polyphenol

詳細情報

• CRID: 1390001204633402112
• NII論文ID: 130001872186
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.35.984
• COI: 1:STN:280:DC%2BC38jgslCrug%3D%3D
• ISSN: 13475215
• ISSN: 09186158
• NDL書誌ID: 023665790
• PubMed: 22687544
• Web Site: http://id.ndl.go.jp/bib/023665790
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I023665790
• Web Site: https://www.jstage.jst.go.jp/article/bpb/35/6/35_b12-00044/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2013046505
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
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