Differential Induction of Stearoyl-CoA Desaturase 1 and 2 Genes by Fibrates in the Liver of Rats
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- Yamazaki Tohru
- Faculty of Pharmaceutical Sciences, Josai University
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- Okada Hitomi
- Faculty of Pharmaceutical Sciences, Josai University
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- Sakamoto Takeshi
- Faculty of Pharmaceutical Sciences, Josai University
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- Sunaga Katsuyoshi
- Faculty of Pharmaceutical Sciences, Josai University
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- Tsuda Tadashi
- Faculty of Pharmaceutical Sciences, Josai University
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- Mitsumoto Atsushi
- Faculty of Pharmaceutical Sciences, Josai International University
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- Kudo Naomi
- Faculty of Pharmaceutical Sciences, Josai University
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- Kawashima Yoichi
- Faculty of Pharmaceutical Sciences, Josai University
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抄録
The administration of fibrates (fenofibrate, bezafibrate and clofibric acid) to rats induced stearoyl-CoA desaturase (SCD) in the liver, and increased relative expression of mRNAs encoding SCD1 and SCD2 in dose- and time-dependent manners. The magnitudes of the increases in SCD2 mRNA level caused by fenofibrate and clofibric acid were much higher than those of SCD1 at relatively higher doses of the fibrates, and a relatively long time (7 or 14 d) was required for significant induction of SCD2 mRNA expression compared with that of SCD1. Although the absolute number of transcripts for SCD2 was 1,800 times lower than that of SCD1 in the control liver, it was strikingly increased by fibrates. These results suggest that differential regulations operate for the gene expression between SCD1 and SCD2, and that the physiological significance of SCD2 is distinct from that of SCD1 in the liver.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 35 (1), 116-120, 2012
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204632425088
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- NII論文ID
- 130001872334
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- NII書誌ID
- AA10885497
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- COI
- 1:STN:280:DC%2BC387isVCntw%3D%3D
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 024029907
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- PubMed
- 22223347
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可