Effects of Sulfaphenazole after Collagenase-Induced Experimental Intracerebral Hemorrhage in Rats

• Hama Sayuri

  Laboratory for Brain Science, Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University

• Ishihara Yasuhiro

  Laboratory of Molecular Brain Science, Graduate School of Integrated Arts and Sciences, Hiroshima University

• Watanabe Masatomo

  Laboratory of Molecular and Cellular Neurosciences, Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University

• Danjo Sonoko

  Laboratory for Brain Science, Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University Department of Neuropsychiatry, School of Medicine, Kagawa University

• Nakamura Yu

  Department of Neuropsychiatry, School of Medicine, Kagawa University

• Itoh Kouichi

  Laboratory for Brain Science, Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University Laboratory of Molecular and Cellular Neurosciences, Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University

Abstract

Treatment of intracerebral hemorrhage is often pointless, although considerable effort has been devoted to developing treatments for ischemic stroke. The purpose of this study was to determine the influence of drugs in improving neurological outcomes with pharmaceutical therapy after intracerebral hemorrhage. The free-radical hypothesis for intracerebral hemorrhage is based on the cytotoxicity triggered by blood components and its degradation products, such as heme and iron as a potent pro-oxidant atom. Sulfaphenazole (SPZ) has a different mechanism such as reactive oxygen species scavenging, in addition to the inhibition of superoxide production by cytochrome P450. The present study investigated the properties of SPZ in collagenase-induced intracerebral hemorrhage rat brain damage. The results show that systemic SPZ treatment after intracerebral hemorrhage reduces striatal dysfunction, the elevation of lipid peroxidation, and brain edema in the rat. These results suggest that SPZ is a potentially effective therapeutic approach for intracerebral hemorrhage as the effect of SPZ was initiated for either 1 h or 3 d post-intracerebral hemorrhage.

Journal

• Biological and Pharmaceutical Bulletin

  Biological and Pharmaceutical Bulletin 35 (10), 1849-1853, 2012

  The Pharmaceutical Society of Japan

Keywords

• intracerebral hemorrhage
• magnetic resonance imaging
• striatum
• brain edema
• rotation behavior
• sulfaphenazole

Details

• CRID: 1390001204633523840
• NII Article ID: 130001872384
• NII Book ID: AA10885497
• DOI: 10.1248/bpb.b12-00525
• COI: 1:STN:280:DC%2BC3s%2FisF2mtw%3D%3D
• ISSN: 13475215
• ISSN: 09186158
• NDL BIB ID: 023973513
• PubMed: 23037177
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I023973513
• Web Site: https://www.jstage.jst.go.jp/article/bpb/35/10/35_b12-00525/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2013124458
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed