Initial Detection of a Circular Genome Deletion in a Naturally Bovine Papillomavirus-Infected Sample

DOI Web Site Web Site PubMed 1 Citations 18 References
  • DONG Jianbao
    Department of Veterinary Microbiology, University of Miyazaki, 1-1 Gakuen Kibanadai Nishi, Miyazaki 889-2192, Japan Japan Society for the Promotion of Science, 8 Ichibancho Chiyoda-ku, Tokyo 102-8472, Japan The United Graduate School of Veterinary Science, Yamaguchi University, 1677–1 Yoshida, Yamaguchi 753–8511, Japan
  • ZHU Wei
    Department of Veterinary Microbiology, University of Miyazaki, 1-1 Gakuen Kibanadai Nishi, Miyazaki 889-2192, Japan Japan Society for the Promotion of Science, 8 Ichibancho Chiyoda-ku, Tokyo 102-8472, Japan
  • GOTO Yoshitaka
    Department of Veterinary Microbiology, University of Miyazaki, 1-1 Gakuen Kibanadai Nishi, Miyazaki 889-2192, Japan
  • HAGA Takeshi
    Division of Infection Control and Disease Prevention, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1–1–1 Yayoi, Bunkyo-Ku, Tokyo 113–8657, Japan

Search this article

Abstract

Bovine papillomavirus type 12 (BPV-12) was recently identified in epithelial papillomas on the cattle tongue in our previous study. Along with the full-length genome, one deleted circular genome, named BPV-12-del, was detected in the same papilloma lesion. BPV-12-del is 3363 base pairs in length, and a total of 3,384 base pairs, including E1, E2 and E4 genes and partial E7 and L2 ORFs, were deleted compared with the complete genome. Real-time PCR results showed that the percentage of BPV-12-del was 42% of the total genomes in the sample. Southern Blot analysis also confirmed the presence of the deleted genome. This is the first report describing a circular genome deletion detected in a naturally BPV-infected sample.

Journal

Citations (1)*help

See more

References(18)*help

See more

Related Projects

See more

Keywords

Details 詳細情報について

Report a problem

Back to top