効果発現パターンにより抗がん薬を分類するための基礎的検討  [in Japanese] Basic Investigation for Classification of Anticancer Drugs by Pharmacological Effects  [in Japanese]

Access this Article

Author(s)

    • 小林 正紀 Kobayashi Masaki
    • 北海道大学大学院薬学研究院臨床薬剤学研究室 Laboratory of Clinical Pharmaceutics and Therapeutics, Faculty of Pharmaceutical Sciences, Hokkaido University
    • 板垣 史郎 [他] Itagaki Shirou
    • 北海道大学大学院薬学研究院臨床薬剤学研究室 Laboratory of Clinical Pharmaceutics and Therapeutics, Faculty of Pharmaceutical Sciences, Hokkaido University
    • 平野 剛 Hirano Takeshi
    • 北海道大学大学院薬学研究院臨床薬剤学研究室 Laboratory of Clinical Pharmaceutics and Therapeutics, Faculty of Pharmaceutical Sciences, Hokkaido University
    • 武隈 洋 Takekuma Yoh
    • 北海道大学大学院薬物動態学研究室 Laboratory of Phamacokinetics, Faculty of Pharmaceutical Sciences, Hokkaido University
    • 菅原 満 Sugawara Mitsuru
    • 北海道大学大学院薬物動態学研究室 Laboratory of Phamacokinetics, Faculty of Pharmaceutical Sciences, Hokkaido University
    • 井関 健 Iseki Ken
    • 北海道大学大学院薬学研究院臨床薬剤学研究室|北海道大学病院薬剤部 Laboratory of Clinical Pharmaceutics and Therapeutics, Faculty of Pharmaceutical Sciences, Hokkaido University|Department of Pharmacy, Hokkaido University Hospital

Abstract

  The most effective drugs based on the type of cancer are chosen for chemotherapy. Tumor cells can be targeted at the DNA, RNA or protein level, and most of the classical anticancer drugs interact with tumor DNA in a time-dependent manner or a concentration-dependent manner. However, it has been unclear to date whether a combination therapy is carried out by using exact classification. Thus it is necessary to reclassify a great number of anticancer drugs. We propose a new classification system based on pharmacological effects of anticancer drugs. Classification of four anticancer drugs (cisplatin, carboplatin, paclitaxel and gemcitabine) was performed by the 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. The four anticancer drugs were grouped by IC<sub>50</sub> values (inhibitory concentration, 50%) in a time-dependent manner and a concentration-dependent manner. The present approach may be combined to enhance the chemosensitivity, improve the dose of cytotoxic drugs and evaluate the effects of novel anticancer drugs.<br>

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 132(6), 777-783, 2012

    The Pharmaceutical Society of Japan

Codes

  • NII Article ID (NAID)
    130001888693
  • NII NACSIS-CAT ID (NCID)
    AN00284903
  • Text Lang
    JPN
  • Article Type
    journal article
  • ISSN
    0031-6903
  • NDL Article ID
    023818474
  • NDL Call No.
    Z19-411
  • Data Source
    NDL  IR  J-STAGE 
Page Top