TRIC(trimeric intracellular cation)-Aチャネルは血管平滑筋において血圧調節に寄与する

• 山崎 大樹

  京都大学大学院薬学研究科生体分子認識学分野

書誌事項

タイトル別名

• TRIC(Trimeric Intracellular Cation)-A Channels Contribute to Blood Pressure Maintenance in Vascular Smooth Muscle
• TRIC(trimeric intracellular cation)-Aチャネル ワ ケッカン ヘイカツキン ニ オイテ ケツアツ チョウセツ ニ キヨ スル

抄録

  TRIC (trimeric intracellular cation) channel subtypes, namely TRIC-A and TRIC-B, are intracellular monovalent cation channels postulated to mediate counter-ion movements facilitating physiological Ca²⁺ release from intracellular stores. Tric-a-knockout mice developed hypertension during the daytime due to enhanced myogenic tone in resistance arteries. There are two Ca²⁺ release mechanisms in vascular smooth muscle cells (VSMCs); incidental opening of ryanodine receptors (RyRs) generates local Ca²⁺ sparks to induce hyperpolarization, while agonist-induced activation of inositol trisphosphate receptors (IP₃Rs) evokes global Ca²⁺ transients causing contraction. Tric-a gene ablation inhibited RyR-mediated hyperpolarization signaling to stimulate voltage-dependent Ca²⁺ influx, and adversely enhanced IP₃R-mediated Ca²⁺ transients by overloading Ca²⁺ stores in VSMCs. Therefore, TRIC-A channels contribute to maintaining blood pressure in vascular smooth muscles.<br>

収録刊行物

• 薬学雑誌

  薬学雑誌 132 (9), 1037-1043, 2012-09-01

  公益社団法人 日本薬学会

キーワード

• trimeric intracellular cation
• vascular smooth muscle cell
• hyperpolarization

詳細情報

• CRID: 1390282681105248640
• NII論文ID: 130001888722
• NII書誌ID: AN00284903
• DOI: 10.1248/yakushi.132.1037
• COI: 1:STN:280:DC%2BC3s%2Fht1ChsA%3D%3D
• ISSN: 13475231
• ISSN: 00316903
• NDL書誌ID: 023961770
• PubMed: 23023421
• Web Site: http://id.ndl.go.jp/bib/023961770
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I023961770
• Web Site: https://www.jstage.jst.go.jp/article/yakushi/132/9/132_1037/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2013047697
• 本文言語コード: ja
• データソース種別:
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  • NDL
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