Death Domain-associated Protein (DAXX)-mediated Regulation of Transcription and Cell Death

• Muromoto Ryuta

  Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University

Bibliographic Information

Other Title

• Death domain-associated protein（DAXX）による転写調節と細胞死
• Death domain-associated protein(DAXX)ニ ヨル テンシャ チョウセツ ト サイボウシ

Abstract

  Death domain-associated protein (DAXX) is a multifunctional protein that modulates both cell death and transcription. DAXX predominantly localizes in the nucleus and regulates the transcription of genes. Several studies have indicated that DAXX is a mediator of lymphocyte death and/or growth suppression, although it is still unclear whether DAXX pro-cell death function is dependent on its transcriptional functions. We found that DAXX suppresses the gp130/STAT3-dependent cell growth and that DAXX interacts with STAT3 and inhibits its DNA-binding activity. Here we will discuss recent developments in our understanding of the nuclear functions of DAXX.<br>

Journal

• YAKUGAKU ZASSHI

  YAKUGAKU ZASSHI 132 (9), 979-984, 2012-09-01

  The Pharmaceutical Society of Japan

Keywords

• death domain-associated protein (DAXX)
• transcriptional repression
• cell death
• signal transducer and activator of transcription 3 (STAT3)

Details

• CRID: 1390001206128543232
• NII Article ID: 130001888732
• NII Book ID: AN00284903
• DOI: 10.1248/yakushi.132.979
• COI: 1:STN:280:DC%2BC3s%2Fht1Citg%3D%3D
• ISSN: 13475231
• ISSN: 00316903
• NDL BIB ID: 023961085
• PubMed: 23023413
• Web Site: http://id.ndl.go.jp/bib/023961085
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I023961085
• Web Site: https://www.jstage.jst.go.jp/article/yakushi/132/9/132_979/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2013047691
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed