DNA Methylation in Peripheral Blood: A Potential Biomarker for Cancer Molecular Epidemiology

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Author(s)

    • Li Lian
    • Department of Preventive Medicine, Seoul National University College of Medicine|Cancer Research Institute, Seoul National University College of Medicine|Department of Epidemiology and Biostatistics, Tianjin Medical University Cancer hospital and Institute
    • Fang Jing-Yuan
    • Shanghai Institute of Digestive Disease, Renji Hospital, Shanghai Jiao-Tong University School of Medicine
    • Kim Woo Ho
    • Department of Pathology, Seoul National University College of Medicine
    • Yuasa Yasuhito
    • Department of Molecular Oncology, Tokyo Medical and Dental University
    • Kang Daehee
    • Department of Preventive Medicine, Seoul National University College of Medicine|Cancer Research Institute, Seoul National University College of Medicine|Department of Biomedical Sciences, Graduate School of Seoul National University
    • Choi Ji-Yeob
    • Department of Biomedical Sciences, Graduate School of Seoul National University
    • Lee Kyoung-Mu
    • Department of Environmental Health, Korea National Open University
    • Sung Hyuna
    • Department of Biomedical Sciences, Graduate School of Seoul National University
    • Park Sue K.
    • Department of Preventive Medicine, Seoul National University College of Medicine|Cancer Research Institute, Seoul National University College of Medicine|Department of Biomedical Sciences, Graduate School of Seoul National University
    • Oze Isao
    • Division of Epidemiology and Prevention, Aichi Cancer Center
    • Pan Kai-Feng
    • Department of Cancer Epidemiology, Peking University School of Oncology, Beijing Cancer Hospital & Institute
    • You Wei-Cheng
    • Department of Cancer Epidemiology, Peking University School of Oncology, Beijing Cancer Hospital & Institute
    • Chen Ying-Xuan
    • Shanghai Institute of Digestive Disease, Renji Hospital, Shanghai Jiao-Tong University School of Medicine

Abstract

Aberrant DNA methylation is associated with cancer development and progression. There are several types of specimens from which DNA methylation pattern can be measured and evaluated as an indicator of disease status (from normal biological process to pathologic condition) and even of pharmacologic response to therapy. Blood-based specimens such as cell-free circulating nucleic acid and DNA extracted from leukocytes in peripheral blood may be a potential source of noninvasive cancer biomarkers. In this article, we describe the characteristics of blood-based DNA methylation from different biological sources, detection methods, and the factors affecting DNA methylation. We provide a comprehensive literature review of blood-based DNA methylation as a cancer biomarker and focus on the study of DNA methylation using peripheral blood leukocytes. Although DNA methylation patterns measured in peripheral blood have great potential to be useful and informative biomarkers of cancer risk and prognosis, large systematic and unbiased prospective studies that consider biological plausibility and data analysis issues will be needed in order to develop a clinically feasible blood-based assay.

Journal

  • Journal of Epidemiology

    Journal of Epidemiology 22(5), 384-394, 2012

    Japan Epidemiological Association

Codes

  • NII Article ID (NAID)
    130001913612
  • Text Lang
    ENG
  • ISSN
    0917-5040
  • Data Source
    J-STAGE 
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