A Multicenter Study Design to Assess the Clinical Usefulness of Semi-Automatic Measurement of Flow-Mediated Vasodilatation of the Brachial Artery

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    • Kario Kazuomi
    • Division of Cardiovascular Medicine, Jichi Medical University School of Medicine
    • Inoue Teruo
    • Department of Cardiovascular Medicine, Dokkyo Medical University
    • Koba Shinji
    • Department of Medicine, Division of Cardiology, Showa University School of Medicine
    • Watanabe Kentaro
    • Department of Internal Medicine (Divisions of Cardiology, Hepatology, Geriatrics, and Integrated Medicine), Division of Geriatric Medicine, Nippon Medical School
    • Takemoto Yasuhiko
    • Department of Internal Medicine and Cardiology, Osaka City University Graduate School of Medicine
    • Hano Takuzo
    • Medical Education and Population-based Medicine, Postgraduate School of Medicine, Wakayama Medical University
    • Sata Masataka
    • Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School
    • Ishibashi Yutaka
    • Division of Cardiovascular Medicine, Department of Medicine, Shimane University Faculty of Medicine
    • Node Koichi
    • Department of Cardiovascular and Renal Medicine, Saga University
    • Maemura Koji
    • Department of Cardiovascular Medicine, Course of Medical and Dental Sciences, Graduate School of Biomedical Sciences, Nagasaki University
    • Kohro Takahide
    • Department of Translational Research for Healthcare and Clinical Science, Graduate School of Medicine, The University of Tokyo
    • Ohya Yusuke
    • The Third Department of Internal Medicine, University of the Ryukyus
    • Furukawa Taiji
    • Department of Internal Medicine, Teikyo University School of Medicine
    • Ito Hiroshi
    • Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
    • Higashi Yukihito
    • Department of Cardiovascular Physiology and Medicine, Hiroshima University Graduate School of Biomedical Science
    • Takase Bonpei
    • Division of Biomedical Engineering, National Defense Medical College Research Institute
    • Suzuki Toru
    • Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
    • Ishizu Tomoko
    • Cardiovascular Division, Institute of Clinical Medicine, University of Tsukuba
    • Ueda Shinichiro
    • Department of Clinical Pharmacology and Therapeutics, University of the Ryukyus School of Medicine
    • Yamazaki Tsutomu
    • Department of Clinical Epidemiology and Systems, Faculty of Medicine, The University of Tokyo
    • Furumoto Tomoo
    • Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine


Flow-mediated vasodilatation of the brachial artery (FMD) is a marker which is related to endothelial nitric oxide bioavailability. Commercially available ultrasound machines equipped with online computer-assisted semi-automatic analysis software to measure FMD have recently become available in Japan. These devices enable more convenient examination, enhanced reproducibility of FMD measurement, and a shortened examination time. Using such devices, in the present multicenter prospective study we propose to: 1) establish standardized FMD values and determine the annual rates of FMD change in healthy subjects; 2) confirm the predictive value of FMD for future cardiovascular events in Japanese subjects; 3) evaluate the potential usefulness of a multimarker strategy, including measurements of FMD, pulse-wave velocity (PWV), ankle-brachial pressure index, biochemical markers, and proteomic biomarkers obtained by mass spectroscopic analysis to assess the prognosis of subjects with coronary artery disease; and 4) clarify the usefulness of FMD measurement to predict the rate of progression of carotid atherosclerosis, arterial stiffness and microalbuminuria in subjects with hypertension or diabetes mellitus. In total, we estimate that approximately 4000 Japanese subjects in 3 different study groups will eventually be enrolled in this prospective observational investigation. We anticipate that the present study will provide important evidence for the usefulness of FMD measurement in the risk stratification for cardiovascular disease.


  • International Heart Journal

    International Heart Journal 53(3), 170-175, 2012

    International Heart Journal Association


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