Comparison of Analytical Performance of Two Single-Step Measurement Devices of B-Type Natriuretic Peptide

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  • Ishida Junichi
    Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
  • Suzuki Toru
    Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo Department of Ubiquitous Preventive Medicine, Graduate School of Medicine, The University of Tokyo
  • Aizawa Kenichi
    Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
  • Sawaki Daigo
    Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo Department of Ubiquitous Preventive Medicine, Graduate School of Medicine, The University of Tokyo
  • Nagai Ryozo
    Jichi Medical University

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Abstract

Rapid measurement of B-type natriuretic peptide (BNP) plays a practical role in the diagnosis of congestive heart failure. Analytical evaluation of a new small-footprint immunochromatography reader of BNP (Rapidpia® ) was performed and compared with the commercially available SHIONOSPOT® Reader as the index. The new BNP assay had a within-run coefficient of variation (CV) of 9.0% and a between-run CV of 2.1%. Correlations between whole blood and plasma samples and those with the index SHIONOSPOT® Reader were y = 0.93x + 0.88, R2 = 0.98 and y = 1.08x - 6.67, R2 = 0.93, respectively. Based on our findings, the two point-of care (POC) assays for BNP, Rapidpia® and SHIONOSPOT® Reader, showed comparable results.

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