A 5-HT_2A Receptor Antagonist, Sarpogrelate Hydrochloride, Improves the Microcirculation in Patients with Peripheral Arterial Disease

• Jibiki Masatoshi

  Department of Vascular Surgery, Tokyo Medical and Dental University, Tokyo, Japan

• Kudo Toshifumi

  Department of Vascular Surgery, Tokyo Medical and Dental University, Tokyo, Japan

• Toyofuku Takahiro

  Department of Vascular Surgery, Tokyo Medical and Dental University, Tokyo, Japan

• Inoue Yoshinori

  Department of Vascular Surgery, Tokyo Medical and Dental University, Tokyo, Japan

Bibliographic Information

Other Title

• 塩酸サルポグレラートによる末梢動脈閉塞症に対する微小循環の改善

Abstract

We assessed whether sarpogrelate hydrochloride improves the microcirculation in patients with peripheral artery disease, by measuring the transcutaneous oxygen tension (tcPO₂). The tcPO₂ was measured in the dorsum pedis of 13 patients before and after 2 weeks of sarpogrelate hyrochloride treatment (300 mg/day). The 26 legs were classified into 2 groups: those with a tcPO₂ (A) <50 mmHg and those >50 mmHg (B). There were significant difference in the findings noted before administration and those between the first treatment and 2 weeks into therapy. There were significant differences in the findings between before and after administration in the first treatment. These findings suggest that sarpogrelate hydrochloride improves the microcirculation in legs with a tcPO₂ <50 mmHg.

Journal

• The Journal of Japanese College of Angiology

  The Journal of Japanese College of Angiology 52 (May), 243-246, 2012

  Japanese College of Angiology

Keywords

• 5-hydroxytryptamine (5-HT)
• 5-HT_2A receptor blocker
• microcirculation
• collateral
• vascular spasm

Details

• CRID: 1390282679879936896
• NII Article ID: 130001922100
• DOI: 10.7133/jca.52.243
• ISSN: 18808840
• ISSN: 03871126
• Web Site: https://search.jamas.or.jp/link/ui/2012332368
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed