組織内エネルギー代謝計測との併用による循環病態解析 Combined Use of Near-infrared Spectroscopy with 31P-Magnetic Resonance Spectroscopy to Study Cardiovascular Pathophysiology

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Author(s)

    • 沖田 孝一 Okita Koichi
    • 北翔大学生涯スポーツ学部スポーツ教育学科 Department of Sport Education, Hokusho University, Hokkaido, Japan

Abstract

要旨:循環障害を有する疾患の動的病態を解析するには,中心循環のみならず末梢組織の血流(酸素供給)および筋内代謝を調べる必要がある。後者は,磁気共鳴分光法により測定可能であるが,血流測定に用いられる血管内カテーテル,プレチスモグラフィおよび超音波ドップラーは,必ずしも局所筋血流を評価できるわけではない。われわれは,磁気共鳴分光法と近赤外線分光法を用いた循環器疾患の病態解析を行ってきたので,その有用性を概説する。

Abstract: In order to better understand the pathophysiology of cardiovascular diseases, both peripheral muscle metabolism and blood flow should be examined. Conventionally, blood flow measurements were performed by venous occlusion plethysmography or catheter based procedures, which evaluate non-selective blood flow. Plethysmography measures the whole limb blood flow, including the flow in skin and non-exercising muscles. A catheter is usually inserted into the large vein and also provides the whole limb blood flow measurement. In contrast, near-infrared spectroscopy might provide information about the nutritive flow in localized exercising muscle. A combined use of NIRS with <sup>31</sup>P-magnetic resonance spectroscopy, which can measure muscle metabolism, is a novel tool to elucidate the pathophysiology in cardiovascular disorders.

Journal

  • The Journal of Japanese College of Angiology

    The Journal of Japanese College of Angiology 52(February), 109-114, 2012

    Japanese College of Angiology

Codes

  • NII Article ID (NAID)
    130001922144
  • Text Lang
    UNK
  • ISSN
    0387-1126
  • Data Source
    J-STAGE 
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