プラズマクラスターイオンのダニアレルゲン低減による通年性アレルギー性鼻炎と疲労に対する軽減効果  [in Japanese] Effect of Plasma Cluster Ions on Attenuating Chronic Allergic Rhinitis and Fatigue by Mite Allergen Reduction  [in Japanese]

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Abstract

本試験では,プラズマクラスターイオンのダニアレルゲン低減による通年性アレルギー性鼻炎および疲労に対する効果について検証するため,健常成人男女を対象としたランダム化二重盲検 2 試験区クロスオーバー試験を実施した.ヤケヒョウヒダニ特異的 IgE 陽性であり,ハウスダストによるアレルギー性鼻炎の諸症状を有する 13 名において,プラズマクラスターイオン 2.5 万個/cm<sup>3</sup> またはイオンなしの試験室で,ダニアレルゲンを播種し 4 時間の精神負荷作業を実施した.その後,試験室外で 2 時間の回復期を設定した.<br> その結果,プラズマクラスターイオンはダニアレルゲンを 80~90%低減することにより,アレルギー性鼻炎の症状である鼻づまりを緩和,QOL の低下を抑制し,通年性アレルギー性鼻炎に対して効果を有すること,さらに精神作業負荷中のパフォーマンスの低下を抑制し,疲労に対しても効果有することが明らかとなった.<br>

<b>Objective</b>: Plasma cluster ions consist of positive and negative ions and are known to suppress the activity of total bacteria, mold fungi, viruses and allergens floating in the air. In terms of inactivating mite allergens, it was reported that plasma cluster ions suppressed the symptoms of atopic dermatitis in mice. In the present study we investigated the effect of plasma cluster ions on attenuating chronic allergic rhinitis and fatigue induced by mite allergens in humans.<br> <b>Design</b>: Sixteen subjects with specific immunoglobulin E (IgE) positive to <i>Dermatophagoides pteronyssinus</i>, who had symptoms of allergic rhinitis caused by house dust participated in a randomized double-blinded crossover trial. Subjects occupied a mite allergen challenge room and performed mental task for 4 hours with 25,000/cm<sup>3</sup> plasma cluster ions or without plasma cluster ions and rested for 2 hours outside of the room. We measured mite allergens (Der p1) on the floor using plastic dishes (90 mm diameter) placed at 5 points in the room. We also investigated the symptoms of allergic rhinitis using the Japanese Allergic Rhinitis Standard QOL Questionnaire (JRQLQ) during the 4-hour load and 2-hour rest and performance by Uchida-Kraepelin psychodiagnostic test during the 4-hour load.<br> <b>Result</b>: Plasma cluster ions inactivated 80–90% of Der p1 and attenuated the symptoms of nasal congestion in JRQLQ. Moreover, plasma cluster ions inhibited fatigue-induced impaired performance in Uchida-Kraepelin psychodiagnostic test compared to the case without the ions.<br> <b>Conclusion</b>: Plasma cluster ions reduce mite allergens and are effective for attenuating chronic allergic rhinitis and fatigue.<br>

Journal

  • Japanese Journal of Complementary and Alternative Medicine

    Japanese Journal of Complementary and Alternative Medicine 9(1), 19-30, 2012

    The Japanese Society for Complementary and Alternative Medicine

Cited by:  1

Codes

  • NII Article ID (NAID)
    130001923983
  • NII NACSIS-CAT ID (NCID)
    AA12095429
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    1348-7922
  • NDL Article ID
    023685458
  • NDL Call No.
    Z74-E199
  • Data Source
    CJPref  NDL  J-STAGE 
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