Intra-abdominal fat area is a predictor for new onset of individual components of metabolic syndrome: MEtabolic syndRome and abdominaL ObesiTy (MERLOT study)

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Author(s)

    • NAKAO Yoko M. NAKAO Yoko M.
    • Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine|EBM Research Center, Kyoto University Graduate School of Medicine
    • YASUNO Shinji [他] NAKAO Kazuwa
    • Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine|EBM Research Center, Kyoto University Graduate School of Medicine
    • YASUNO Shinji
    • EBM Research Center, Kyoto University Graduate School of Medicine
    • NAKAO Kazuhiro
    • Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine
    • TANAKA Sachiko
    • EBM Research Center, Kyoto University Graduate School of Medicine
    • IDA Midori
    • Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine
    • HIRATA Masakazu
    • Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine
    • HOSODA Kiminori
    • Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine

Abstract

<b>Objective</b>: To investigate the significance of intra-abdominal fat area (IAFA) on new onset of individual components of the metabolic syndrome: high blood pressure, dyslipidemia, or hyperglycemia. <b>Methods</b>: We conducted a longitudinal study using checkup data of a hospital from 1994 to 2010. Of 25,255 subjects, we examined 1,380 Japanese, who underwent computed tomography to measure IAFA and had no metabolic syndrome components at baseline. <b>Results</b>: During 3.6 years of the mean follow-up period, one of metabolic syndrome components occurred in 752 subjects. Of three components, high blood pressure was more prevalent. The multiple Cox regression analysis disclosed that IAFA is significantly associated with onset of metabolic syndrome components (HR: 1.05 per 10 cm<sup>2</sup>, 95%CI: 1.03–1.07). This finding was independent of BMI, and significant even in non-obese individuals with body mass index <25 kg/m<sup>2</sup>. <b>Conclusions</b>: MERLOT study demonstrates that IAFA is an independent predictor for new onset of individual components of the metabolic syndrome, even in non-obese healthy Japanese.<BR><BR>(Communicated by Masanori OTSUKA, M.J.A.)

Journal

  • Proceedings of the Japan Academy, Series B

    Proceedings of the Japan Academy, Series B 88(8), 454-461, 2012

    The Japan Academy

Codes

  • NII Article ID (NAID)
    130001924760
  • NII NACSIS-CAT ID (NCID)
    AA00785485
  • Text Lang
    ENG
  • ISSN
    0386-2208
  • NDL Article ID
    024039146
  • NDL Call No.
    Z53-T495
  • Data Source
    NDL  J-STAGE 
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