Pathological Examination of Lung Tissues in Influenza A Virus-Infected Mice

• Muto Nilton Akio

  Division of Molecular Pathobiology, Research Center for Zoonosis Control, Hokkaido University

• Sunden Yuji

  Laboratory of Comparative Pathology, Graduate School of Veterinary Medicine, Hokkaido University

• Hattori Tomoe

  Division of Bioresource, Research Center for Zoonosis Control, Hokkaido University Graduate School of Life Science, Hokkaido University

• Fujikura Daisuke

  Division of Infection and Immunity, Research Center for Zoonosis Control, Hokkaido University

• Nakayama Yosuke

  Institute for Genetic Medicine, Hokkaido University

• Miyazaki Tadaaki

  Institute for Genetic Medicine, Hokkaido University Global COE Program, Hokkaido University, Research Center for Zoonosis Control

• Maruyama Mitsuo

  National Center for Geriatrics and Gerontology

• Kimura Takashi

  Division of Molecular Pathobiology, Research Center for Zoonosis Control, Hokkaido University

• Sawa Hirofumi

  Division of Molecular Pathobiology, Research Center for Zoonosis Control, Hokkaido University Global COE Program, Hokkaido University, Research Center for Zoonosis Control

抄録

This study examined pathological changes in the lung tissues of young and aged mice infected with influenza virus. Young mice inoculated with influenza virus showed body weight loss at 4 days post-infection (dpi), meanwhile body weight decrease started from 9 dpi in the aged mice. We histopathologically examined the lungs of these mice. Immunohistochemical examination revealed that viral antigen-positive bronchiolar and alveolar epithelial cell numbers at 3 dpi were significantly higher in young mice than in the aged ones. Further, viral antigen-positive cells were observed at 9 dpi in the aged mice, but not in the young ones. Diffuse and severe bronchointerstitial pneumonia characterized by the accumulation of polymorphonuclear leukocytes (PMNs) was observed in young mice at 6 dpi. Histopathological changes in the aged mice were milder than those in the young mice. Moreover, T cell and macrophage accumulation in the lungs was significantly higher in the young mice than in the aged mice at 9 dpi. These results suggest that there may be a correlation between the relatively low level of infiltration of PMNs, macrophages, and T lymphocytes and the delayed body weight loss and longer lasting infections observed in the lungs of the aged mice. These findings provide detailed insights into the age-specific course of infection in young and aged populations with associated differences in lung pathology.

収録刊行物

• Japanese Journal of Infectious Diseases

  Japanese Journal of Infectious Diseases 65 (5), 383-391, 2012

  国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会

キーワード

• Infectious Diseases
• Microbiology (medical)
• General Medicine

詳細情報

• CRID: 1390282681218032000
• NII論文ID: 130001931846
• NII書誌ID: AA1132885X
• DOI: 10.7883/yoken.65.383
• ISSN: 18842836
• ISSN: 13446304
• NDL書誌ID: 023971497
• PubMed: 22996210
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I023971497
• Web Site: https://search.jamas.or.jp/link/ui/2014000360
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可