血中Prolactin濃度と甲状腺ホルモン濃度との相関関係について

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  • Hyperbola-Correlation Found between Thyroid Hormones and Prolactin Response to TRH in Hyperthyroidism and Primary Hypothyroidism
  • ケッチュウ Prolactin ノウド ト コウジョウセン ホルモン ノウド

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In order to clarify the correlation between serum levels of thyroid hormone and prolactin response to the thyrotropin-releasing hormone (TRH), untreated hyperthyroidism with diffuse goiter, euthyroid hyperthyroidism with PTU and primary hypothyroidism were employed. Group A (n=7) was untreated hyperthyroidism with mean values of 15.6 ± 0.5μg/ 100ml (T4) and 467.7 ± 80.4ng/100ml (T3); Group B (n=5) was PTU treated hyperthyroidism in euthyroid state within 6 months, with 9.3 ± 0.6μg/100ml (T4) and 174.0 ± 16.1ng/ 100ml (T3); Group C (n=10) consisted of subjects similar to those in group B with 1-2 yrs of euthyroidism, with 8.7 ± 1.4μg/100ml (T4) and 146.2 ± 19.1ng/100ml (T3); Group D consisted of subjects similar to those in groups B and C with a euthyroid state over 2 yrs, with 9.0 ± 0.5μg/100ml (T4) and 122.8 ± 7.1ng/100ml (T3) (n=13); Group E (n=8) was primary hypothyroidism before any treatment with 3.3 ± 0.4μg/100ml (T4) and 51.0 ± 6.6 ng/100ml (T3). Serum values of the thyroid hormones (T4 and T3) fell from group A to group E, and in each group, thyroid hormone levels in serum were considered to be in a relatively constant range over a long term.<BR>Serum levels of TSH, PRL and T3 were determined following a 500μg TRH injection in all groups. Although dissociation between PRL and TSH responses to the TRH provocation was seen in some groups, it seemed that both responses were inversely augmented according to the decrease of serum thyroid hormone levels. Therefore, statistical analyses were performed to elucidate the correlation between the levels of T4, T3 and the maximum level of PRL to the TRH injection. These results clearly indicated that maximum PRL response was in a hyperbola correlation with both thyroid hormones (T3 and T4).

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