Peptides Containing Aminophosphonic Acids. II. The Synthesis of Tripeptide Analogs

• Kiyoshi Yamauchi

  Department of Applied Chemistry, Osaka City University

• Masayoshi Kinoshita

  Department of Applied Chemistry, Osaka City University

• Minoru Imoto

  Department of Applied Chemistry, Osaka City University

抄録

The synthesis of tripeptides containing aminophosphonic acid was attempted as follows. Diethyl phthalylimidomethyl phosphonate (I) was chlorinated with phosphorus pentachloride to the phosphonomonochloridate (II), which was then coupled with amino acid ethyl esters to give the corresponding dipeptides (IIIa—c). The phthalyl groups of III were removed with hydrazine, and the resulting free amines were subsequently combined with phthalyl-amino acids by means of dicyclohexylcarbodiimide to produce the tripeptide analogs (IVa—c) in good yields.

収録刊行物

• Bulletin of the Chemical Society of Japan

  Bulletin of the Chemical Society of Japan 45 (8), 2531-2534, 1972-08-01

  Oxford University Press (OUP)

キーワード

• General Chemistry

詳細情報

• CRID: 1360283694076363904
• NII論文ID: 130001975046
• DOI: 10.1246/bcsj.45.2531
• ISSN: 13480634
• ISSN: 00092673
• Web Site: https://academic.oup.com/bcsj/article-pdf/45/8/2531/55702342/bcsj.45.2531.pdf
• データソース種別:
  • Crossref
  • CiNii Articles