Total Synthesis of <i>Escherichia coli</i> Lipid A, the Endotoxically Active Principle of Cell-Surface Lipopolysaccharide

• Masahiro Imoto

  Department of Chemistry, Faculty of Science, Osaka University

• Hiroyuki Yoshimura

  Department of Chemistry, Faculty of Science, Osaka University

• Tetsuo Shimamoto

  Department of Chemistry, Faculty of Science, Osaka University

• Nobuki Sakaguchi

  Department of Chemistry, Faculty of Science, Osaka University

• Shoichi Kusumoto

  Department of Chemistry, Faculty of Science, Osaka University

• Tetsuo Shiba

  Department of Chemistry, Faculty of Science, Osaka University

Abstract

Chemical syntheses are described of polyacylated β(1→6) glucosamine disaccharide 1,4′-bis(phosphate), which corresponds to the proposed structure of E. coli lipid A, and of its dephospho derivatives. The synthetic bisphosphate proved to be identical with the corresponding natural specimen. The chemical structure of lipid A was thus established.

Journal

• Bulletin of the Chemical Society of Japan

  Bulletin of the Chemical Society of Japan 60 (6), 2205-2214, 1987-06-01

  Oxford University Press (OUP)

Keywords

• General Chemistry

Details

• CRID: 1360565169056198272
• NII Article ID: 130001982033
• DOI: 10.1246/bcsj.60.2205
• ISSN: 13480634
• ISSN: 00092673
• Web Site: https://academic.oup.com/bcsj/article-pdf/60/6/2205/55726217/bcsj.60.2205.pdf
• Web Site: https://search.jamas.or.jp/link/ui/1988113479
• Data Source:
  • Crossref
  • CiNii Articles