The Enantioface-differentiating Hydrogenation of the C=O Double Bond with Asymmetrically Modified Raney Nickel. XXXVIII. The Hydrogenation of Methyl Ketones to Optically Active Secondary Alcohols

• Tsutomu Osawa

  Institute for Protein Research, Osaka University

• Tadao Harada

  Institute for Protein Research, Osaka University

抄録

The enantioface-differentiating (asymmetric) hydrogenation of various methyl ketones (R–COCH3) was carried out over the Raney nickel catalyst modified with (R,R)-tartaric acid and sodium bromide. The presence of an appreciable amount of carboxylic acid in the reaction system was indispensable for a high optical yield. The highest optical yield (74%) was obtained in the hydrogenation of 3,3-dimethyl-2-butanone in the presence of pivalic acid.

収録刊行物

• Bulletin of the Chemical Society of Japan

  Bulletin of the Chemical Society of Japan 57 (6), 1518-1521, 1984-06-01

  Oxford University Press (OUP)

キーワード

• General Chemistry

詳細情報

• CRID: 1360283694078869760
• NII論文ID: 130001984484
• DOI: 10.1246/bcsj.57.1518
• ISSN: 13480634
• ISSN: 00092673
• Web Site: https://academic.oup.com/bcsj/article-pdf/57/6/1518/55671820/bcsj.57.1518.pdf
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