気管支喘息児の非発作時の換気機能と高張食塩水吸入試験に対するipratropium bromideの効果

• 東川 昌紀

  国立療養所南福岡病院小児科

• 梅野 英輔

  国立療養所南福岡病院小児科

• 松本 一郎

  国立療養所南福岡病院小児科

• 小田嶋 博

  国立療養所南福岡病院小児科

• 西間 三馨

  国立療養所南福岡病院小児科

書誌事項

タイトル別名

• Effects of Ipratropium Bromide on Ventilatory Function or on Airway Hyperresponsiveness to Hypertonic Saline Challenge in asymptomatic Asthmatic Children

抄録

The goal of the present study was to evaluate the effects of inhaled anticholinergic agent on ventilatory function and on bronchial hyperresponsiveness to hypertonic saline. Ipratropium bromide (IB) or placebo aerosol were administered into the airways using spacer in 11 asymptomatic asthmatic children with single blind and randomized-crossover fashion.<BR>Decreased MMF and V₅₀observed in these asymptomatic children were significantly improved 30min after IB (40μg) inhalation, but not after placebo.<BR>Airway challenge of hypertonic saline was performed according to the method of Anderson's. Provocative dose of 3.6% hypertonic saline causing a 20% fall in FEV_1.0.(PD₂₀) become significantly higher 30min after the pretreatment with IB than that after placebo. These findings suggest that cholinergic pathways might play a role in the mechanism of small airway narrowing and nonspecific bronchial responsiveness in asymptomatic asthmatic children.

収録刊行物

• 日本小児呼吸器疾患学会雑誌

  日本小児呼吸器疾患学会雑誌 4 (1), 12-17, 1993

  日本小児呼吸器疾患学会

キーワード

• 児気管支喘息
• 抗コリン薬
• 換気機能
• 気道過敏性
• 高張食塩水吸入試験

詳細情報

• CRID: 1390282679397454848
• NII論文ID: 130001998891
• DOI: 10.5701/jjpp.4.12
• ISSN: 21853754
• ISSN: 09183876
• Web Site: https://search.jamas.or.jp/link/ui/1994016864
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可