ラットアジュバント関節炎に対するＨｅ－Ｎｅレーザー照射の効果

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  • 趙 育松
    九州大学生体防御医学研究所臨床免疫学部門
  • 安田 正之
    九州大学生体防御医学研究所臨床免疫学部門
  • 山本 政弘
    九州大学生体防御医学研究所臨床免疫学部門
  • 塩川 左斗志
    九州大学生体防御医学研究所臨床免疫学部門
  • 延永 正
    九州大学生体防御医学研究所臨床免疫学部門

書誌事項

タイトル別名
  • He-Ne laser irradiation against rat adjuvant arthritis.
  • ラットアジュバント カンセツエン ニ タイスル He Ne レーザー ショウシ

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抄録

The therapeutic effect of low-energy He-Ne laser irradiation on rat adjuvant arthritis was evaluated by observing the changes in foot volume and in histology of ankle joints. Five mg/ml of emulsion of Freund's complete adjuvant and tubercle bacilli was given to nine Lewis rats and He-Ne laser irradiation (632.5nm, 8.5mw) was started 4 weeks later. Ten-minute irradiation was given three times a week for 8 weeks on either the right or left foot. A significant decrease in foot volume in the irradiated feet was observed in the first week. The foot volume continuously decreased for 5 weeks, but a significant decrease in the non-irradiated feet was shown only after 6 weeks. The rats were killed at the end of the eighth week and histological changes were compared between the irradiated and the non-irradiated feet. No difference was observed in the bone or cartilage. However, a tendency that the irradiated feet had fewer blood vessels, less cellular infiltrates and stronger fibrosis was found in the synovium.<br>He-Ne laser irradiation seemed to reduce foot swelling faster and accelerate histological changes. Laser irradiation on a joint may be more effective at an early stage of inflammation.

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