Ｃａｒｐｅｒｉｔｉｄｅ（ＳＵＮ　４９３６：α‐ヒト心房性ナトリウム利尿ペプチド）投与による運動誘発左心機能障害の改善

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タイトル別名
  • The Effects of Carperitide(SUN 4936: .ALPHA.-Human Atrial Natriuretic Polypeptide) on Exercise- Induced Impairment of Left Ventricular Function in Patients with Chronic Heart Failure.

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Effects of carperitide on cardiac function during dynamic exercise were studied in 11 patients, aged 50 to 68 years, with chronic heart failure.<BR>Changes in hemodynamic parameters during symptom-limited supine multistage bicycle ergometer exercise testing, in which initial work load of 25 w was increased stepwise by 25 w every 3 min, were compared before and after intra-pulmonary artery infusion of carperitide (0.05 or 0.1μg/kg/min, for 30 min).<BR>Following carperitide infusion at rest, systolic and diastolic blood pressure, systemic vascular resistance and pulmonary artery wedge pressure decreased significantly, while the heart rate increased signficantly.<BR>At the time of peak exercise, the pulmonary artery wedge pressure remained at a lower level (13.5±2.9mmHg ; mean±SEM) after the infusion of carperitide as compared to the case of placebo infusion (25.1±2.4mmHg, p<0.001). Other hemodynamic parameters including blood pressure, heart rate, cardiac index, coronary sinus flow, systemic vascular resistance, coronary vascular resistance, and myocardial oxygen consumption showed no significant diffe- rences between the carperitide and placebo groups.<BR>One of 2 patients receiving 0.1μg/kg/min of carperitide was withdrawn from the study due to the occurrence of abrupt hypotension. None of 9 patients receiving 0.05μg/kg/min experienced any adverse effect.<BR>These results suggest that infusion of carperitide at a moderate dose can exert some beneficial hemodynamic effects on exercise-induced impairment of left ventricular function in patients with chronic heart failure.

収録刊行物

  • 臨床薬理

    臨床薬理 24 (4), 551-562, 1993

    一般社団法人 日本臨床薬理学会

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