新しい睡眠薬450191‐Sの高齢患者における薬物速度論的研究
書誌事項
- タイトル別名
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- Pharmacokinetics of a novel hypnotic, 450191-S, in elderly patients.
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抄録
A new hypnotic, 450191-S, was administered to five elderly patients [cerebral thrombosis: two patients (81 yr and 78 yr), gastric cancer: one patient (61 yr); chronic hepatitis: twopatients (78 yr and 70 yr)]. Pharmacokinetic behaviors of this drug in these patients werecompared with those in healthy volunteers reported in a previous study.<BR>Plasma protein binding ratio of each metabolite and urinary excretion ratio of M-4 inelderly patients were similar to those in healthy volunteers. However, some differencesin plasma concentration time course of metabolites were found between elderly patientsand healthy volunteers. In healthy volunteers, Cmax of M-1 was lower than that of M-2and M-A whereas in elderly patients Cmax of M-1 was higher than M-2 and M-A. Fromthe results of various investigations of the phenomenon, it seems that the higher plasmaconcentration of M-1 in elderly patients may be ascribed to a decrease of first-pass effect.
収録刊行物
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- 臨床薬理
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臨床薬理 19 (3), 617-624, 1988
一般社団法人 日本臨床薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390001205369118848
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- NII論文ID
- 130002046751
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- ISSN
- 18828272
- 03881601
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
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- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可