Poorly Differentiated Neuroendocrine Carcinoma of the Pancreas Responsive to Combination Therapy with Gemcitabine and S-1

  • Yamamoto Mitsuyoshi
    The Third Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, Japan
  • Miyagawa Koichiro
    The Third Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, Japan
  • Hiura Masaaki
    The Third Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, Japan
  • Taguchi Masashi
    The Third Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, Japan
  • Kihara Yasuyuki
    The Third Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, Japan
  • Abe Shintaro
    The Third Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, Japan
  • Shimajiri Shohei
    Department of Pathology and Cell Biology, University of Occupational and Environmental Health, School of Medicine, Japan
  • Harada Masaru
    The Third Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, Japan

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抄録

Poorly differentiated neuroendocrine carcinoma is a very rare malignancy, but it is characterized by agressive histological features and a poor clinical prognosis. We report a 42-year-old man who had poorly differentiated neuroendocrine carcinoma of the pancreas with multiple liver metastases. We administrated combined chemotherapy with S-1 and gemcitabine. This treatment was efficacious and well tolerated, and then this patient obtained objective partial response for 7 months and survived for 13 months after the diagnosis. This case suggests that S-1 and gemcitabine combination produce beneficial responses for patients with this disease.<br>

収録刊行物

  • Internal Medicine

    Internal Medicine 51 (7), 727-732, 2012

    一般社団法人 日本内科学会

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