Recurrence of Chronic Active Epstein-Barr Virus Infection from Donor Cells after Achieving Complete Response Through Allogeneic Bone Marrow Transplantation

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Author(s)

    • Arai Ayako
    • Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan
    • Fujiwara Shigeyoshi
    • Department of Infectious Diseases, National Research Institute for Child Health and Development, Japan
    • Miura Osamu
    • Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan
    • Imadome Ken-Ichi
    • Department of Infectious Diseases, National Research Institute for Child Health and Development, Japan
    • Wang Ludan
    • Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan
    • Wu Nan
    • Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan
    • Kurosu Tetsuya
    • Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan
    • Harigai Masayoshi
    • Department of Pharmacovigilance, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan

Abstract

We report the case of a 35-year-old woman with chronic active Epstein-Barr virus (EBV) infection (CAEBV). She underwent allogeneic bone marrow transplantation (BMT) from an unrelated male donor and achieved a complete response. However, her CAEBV relapsed one year after BMT. EBV-infected cells proliferated clonally and revealed a 46XY karyotype. In addition, the infecting EBV strain differed from that detected before BMT. These findings indicated that her disease had developed from donor cells. This is the first report of donor cell-derived CAEBV that recurred after transplantation, suggesting that host factors may be responsible for the development of this disease.<br>

Journal

  • Internal Medicine

    Internal Medicine 51(7), 777-782, 2012

    The Japanese Society of Internal Medicine

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